Survey on Intra-Peritoneal Injection of Mercuric Chloride on Blood Albumin and Liver Enzymes

Nahid Bolbol Haghighi, Sahar Molzemi, Hoosin Harati Por, Shahram Molzemi, Fatemeh Sadat Alamal-Hoda, Amir Hossein Ashenaii, Seyed Reza Mousavi, Mohammad Reza Jafari, Amir Hassan Zade, Mahbobe Sedighi


Background :

The rapid  development of  the mining and industry activities increased and many toxic metals  in the environment of the earth's crust has been dissipated  and t  has taken  risks to human exposure, inhalation. Today evidence of many  diseases associated with environmental  factors  harmful to repellent Bio systems is increasing gradually , The majority of these factors  were man-made and the activities associated with heavy metals  was a major threat for  human health.

Mercury has the most toxic non-radioactive  element that was already known. The purpose of this study was to investigate the effect of mercuric chloride intra peritoneally on blood albumin and some liver enzymes.

Materials and Methods:

In this study, 30 male Wistar rats randomized selected  into 6 groups (1 control group, and experimental groups of 1, 2, 3, 4, 5). In control group adequate serum physiology, and in experimental groups a dose of mercuric chloride infused into peritoneal cavity for 7 days. The amount of mercuric chloride infused were 1 mg/kg in 1st group, 2 mg/kg in group 2, 5 mg/kg in group 3, 7 mg/kg in group 4, and 10 mg/kg in the fifth group every other day for for 7 days. After the 7 days blood samples, were tested and analyzed.


In this study, there was a significant relation between decrease in albumin levels in experimental groups compared to the control group and a there was significant relation  increase in the amount of transaminases; SGOT and SGPT in the experimental group


This study showed that intra peritoneal injection of mercuric chloride causes the balance were increased.of liver enzymes and serum albumin levels.


Mercuric chloride; Albumin; Liver enzymes; Mouse; Rats; Wistar

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