Correlation of Changes in Serum Pepsinogen 1, Pepsinogen 2 with Helicobacter pylori Eradication

Abstract

Background

H. pylori infection in the stomach was the first major cause of gastritis and peptic ulcer disease and gastric adenocarcinoma and lymphoma (MALT). Evaluation of the infection eradication is important. H. pylori infection was associated with gastric glands dysfunction such as increased serum gastrin and increased secretion of Pepsinogen. In recent years the measurement of serum gastrin and pepsinogen were considered to evaluation of Helicobacter pylori eradication.

Materials and Methods:

In a case - control study, we evaluated the changes of serum pepsinogen type 1 and 2 in H. pylori-positive patients after eradication therapy, and we assessed the correlation of serum pepsinogen type 1 and 2 and with successful eradication therapy.

Results:

Pepsinogen type 1 and 2 serum levels significantly decreased after successful eradication in comparison with unsuccessful eradication. The both 2 markers decreased after 8 weeks of therapy. Pepsinogen 1 by a 41.1% decrease in 8 weeks after eradication had 95% sensitivity and 100% specificity for successful eradication. 64.1% reduction in pepsinogen 2, 8 weeks after treatment had 97.5% sensitivity and specificity for successful eradication.

Conclusion:

According to the findings of this study and other previous studies, changes in the type 2 pepsinogen serum levels, can be a reliable indicator of successful eradication of H-pylori infection. Although our study showed that changes in pepsinogen 1 levels have a sufficient sensitivity and specificity of treatment, but in our study some factors including atrophic gastritis and age that affected on type 1 pepsinogen serum levels, did not considered.