Effect of Ritalin on Blood Albumin and Liver Enzymes in Rat

Nahide Bolbol Haghighi, Sahar Molzemi, Maryam Karimi Mohamadi, Shahram Molzemi



Ritalin (methylphenidate Methylphenidate) is an amphetamine used to treat ADHD, symptoms of Narcolepsy, and some people with depression. This study was to investigate the effect of Ritalin food on blood albumin and some liver enzymes.

Materials and Methods:

In this study, 40 male Wistar rats were randomized into 4 groups (1 control group, and three experimental groups). In the control group physiologic serum and in the experimental groups a dose of mercuric chloride infused into the peritoneal cavity for 30 days. The amount of Ritalin was 2.5 ml in 1st group, 5 ml in group 2, 10 ml group 3, every other day for 30 days. After the due date of the invoice for blood samples, were tested.


There was a significant difference in albumin levels in experimental groups compared to the control group and there was a significant decrease in the amount of liver transaminases; the experimental group compared to the control group.


This study shows that Ritalin causes liver enzymes disrupt the balance and serum albumin levels were increased.


Ritalin; Albumin; Liver enzymes; Mouse; Rats; Wistar

Full Text:


Copyright (c)