Effects of Tramadol on Alanine and Aspartate Aminotransferase

Nahide Bolbol Haghighia, Sahar Molzemi, Mohsen Aminian, Shahram Molzemi



Tramadol narcotic drugs or Epoxied artificial categories is weaker than morphine and stronger than ibuprofen and acetaminophen drug. The aim of this study was to investigate the effect of oral tramadol on some liver enzymes in the rat.

Materials and Methods:

In this study, 60 male Wistar rats were randomized into three groups (one control group, and experimental groups of 1, and 2). In the control group adequate serum physiology and in the experimental groups a dose of mercuric chloride was infused into the peritoneal cavity for 30 days. The first experimental group received 50mg/kg tramadol, and the second experimental group received 100mg/kg methadone daily for 30 days



In this study, a significant increase in the amount of alanine and aspartate transaminases were observed in the experimental group compared with the control group.


This study showed that gavage tramadol can cause disruption in the balance of liver enzymes levels.


Tramadol, Liver enzymes, Mouse, Rats, Wistar

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