Single Nucleotide Polymorphisms as Risk Variants in Crohn’s Disease

Fereshteh Izadi

Abstract


Background:
Crohn’s disease is the most challenging, common type of autoimmune disorders due to which, intestine is inflamed but its causes have not been defined. Although Crohn’s disease has been often thought of as an autoimmune disorder, it can be triggered by whatever that lead to the inflammation in the whole bowel. Henceforth, exploring trade-off among this disease and genomic variants supposedly will enhance the identification of important genes and in turn to the possible therapeutic protocols. The aim of the present study was to identify any association between Crohn’s disease and single nucleotide polymorphisms.

Materials and Methods:
We retrieved single nucleotide polymorphism of genome-wide association studies (GWAS) on Crohn’s disease among which we extracted neighboring genes and expression variants in addition to pathways in which the affected genes are enriched.

Results:
Using GWAS data can help to explain the disease incidence. We noticed that genes harboring single nucleotide polymorphisms in Crohn’s disease were mainly enriched in interleukin pathways in addition to fatty acid and choline metabolism.

Conclusion:
The affected genes obtained by data analysis like fatty acid desaturase (FADS) and solute carrier family 22 (SLC22) could be proposed for future studies in order to clarifying their interactions by confident experiments and cross-sectional studies.


Keywords


Crohn’s disease, eQTL, Single nucleotide polymorphism

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