A Rare Case Report of Gastrointestinal Stromal Tumor Synchronous with Splenic Metastasis

Raheleh Baradaran, Fereshteh Mohammadi, Fatemeh Rahimi Anbarkeh, Abbas Sadeghian, Seyed Hadi Sajjadi


A gastrointestinal stromal tumor (GIST) is the most common intramural mesenchymal tumor of the gastrointestinal tract. Their metastasis to extragastrointestinal organs is rare, especially the spleen. The patient was a 52-year-old man who, with the diagnosis of peritonitis, underwent laparotomy emergently. At the time of surgery, an extensive tumor was seen in the stomach, esophagus, and jejunum, which had metastases to the spleen. Total gastrectomy, esophagojejunostomy, and splenectomy were performed. The morphological studies showed a spindle-cell type of GIST that were positive for CD117 and Discovered on GIST-1 (DOG1). GIST was diagnosed as high-risk and treated with imatinib. In follow-up, he died 5 months after discharge. Here, we reported a case of GIST synchronous with splenic metastasis. Surgeons must alert for possible metastases associated with GISTs, clinical presentation, diagnosis, treatment, and pathological classification.


Gastrointestinal stromal tumor; GIST; Splenic metastasis

Full Text:


Copyright (c) 2023 GOVARESH

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.