Gastrointestinal Challenges in Patients with Epidermolysis Bullosa: Insights from a Cross-Sectional Analysis in Iran
Abstract
Background:
In light of the relatively low prevalence of epidermolysis bullosa and the absence of research focused on gastrointestinal complications in Iran, our study sought to address this gap. Given the limited body of knowledge in this particular area, there is a crucial need to explore and identify gastrointestinal complications in patients with epidermolysis bullosa and understand the associated factors.
Materials and Methods:
The present study was conducted cross-sectionally. 67 patients with epidermolysis bullosa were selected by census and included in the study. Demographic information of patients, including age and sex, was recorded. The patients were fully examined by a gastroenterology specialist, and a history was taken for gastrointestinal diseases. The data were statistically analyzed using the SPSS software, version 28.
Results:
67 individuals with epidermolysis bullosa were evaluated for this investigation. The patients had simplex (23.9%), dystrophic (29.9%), junctional (4.5%), and unknown (41.8%) varieties of epidermolysis bullosa. Halitosis (64.2%), constipation (59.7%), food stuck in the throat (56.7%), mouth ulcers (52.2%), flatulence (50.7%), stomach discomfort and unpleasant taste in the mouth (47.8%), difficult swallowing (44.8%), and reflux (37.3%) were the most frequent gastrointestinal problems among these individuals.
Conclusion:
The current study found that gastrointestinal issues are widespread in individuals with epidermolysis bullosa; hence, it is advised that suitable preventative and therapeutic measures be implemented, as well as multispecialty therapy.
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