Effect of Lactobacillus Acidophilus on Adults Habitual Constipation in Gastrointestinal Clinic of Ghaem Hospital in Mashhad: A Pilot Study

Hasan Vosoghinia, Ahmad Khosravi, Hasan Saadatnia, BibiSedigheh Fazli-Bazaz, Monavvar Afzal-Aghaei, Mahtab Shabani, Elham Mokhtari-Amirmadjdi, Shahrzad Mohammadzadeh-Larry, Laeya Kafami-Khorasani, Amir Adhamie, Hamed Javan, Vajiheh Alizadeh


Background: Constipation is a common problemin elderly subjects. Probiotics have been suggested to improve intestinal motility and to reduce fecal enzyme activity. In this study, the effect of lactobacillus acidophilus tablets on elderly subjects was compared with placebo. 

Materials andMethods: Elderly subjects (n = 48) with chief complaint of constipation were enrolled in a randomly double-blind study. The subjects were divided into 2 groups: control group, receiving placebo every 8 hours for one month, and study group, receiving lactobacillus acidophilus tablet every 8 hours for onemonth. Subjectswith lactose intolerance and other pathologic conditions were omitted.At the end of 4 weeks, all subjects were questioned on the relief of constipation and other symptoms. Response to treatment and complications were compared between the two groups.

Results: In subjects receiving lactobacillus acidophilus, 50%(13 subjects) respondedwell and had relief of constipation, 23.1%(6 subjects) showed relative response and 26.9%(7 subjects) did not respond. In subjects receiving placebo, 40% (6 subjects) had relief of constipation, 13.3% (2 subjects) responded relatively well and in 46.7% (7 subjects) no responsewas seen (p=0.388).Newsignswere observed in 5 subjects (19.2%) receiving lactobacillus acidophilus and 1 subject (6.7%) receiving placebo.After 4 weeks, 2 subjects (7.7%) receiving lactobacillus acidophilus and 1 subject (6.7%) receiving placebo re-experienced constipation.

Conclusion: Some relief of constipation could be observed with lactobacillus acidophilus tablets, but there was no significant difference between the two groups.


Habitual constipation; Lactobacillus acidophilus; Probiotic.

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