Evaluation of Sonogeraphic Index for Insulin Resistance and Metabolic Syndrome in Asymptomatic Fatty Liver Disease

Abstract

Background: The frequency of sonographic report of liver fat infiltration in asymptomatic person is increasing. The aim of this study was evaluation of liver function and detection of frequency of metabolic syndrome and Insulin resistance in asymptomatic persons with fatty liver in sonographic examinations.

Materials and Methods: Seventy six patients with fatty liver in sonographic examination and 78 persons with normal sonographic examination who had similar sex, age and body weight were selected. Patients with history of diabetes mellitus, hyperlipidemia, hypertension who took drugs that induced fatty liver such as amiodaron, diltiazem, metotrexate, tamoxifen and patients with positiveserology for HBS-Ag and HCV-Ab were excluded. Blood pressure, BMI, weight, height, liverenzymes, blood lipids, and fasting insulin level and insulin resistance according to HOMAindex were evaluated.

Results: Mean age was 44.8±9.79 and 42.54±10.7 years for fatty liver patients and normal persons, respectively. Mean systolic and diastolic blood pressures, weight, height, HDL triglyceride, FBS, ALT, 2-hour postprandial glucose level, fasting insulin level and insulin resistancewere significantly higher in fatty liver patients compared with normal persons Fifty percent of fatty liver patients but only %18 of normal persons had metabolic syndrome criteria.

Conclusion: Insulin resistance andmetabolic syndrome are very common in fatty liver persons. It seems that fatty liver is one of the criteria of metabolic syndrome.Patients with fatty liver in sonographic examination should be further evaluated for metabolic syndrome and insulin resistance.