Evaluation of Efficacy of H. pylori Eradication Regimens in Iran: A Systematic Review

Abstract

Background:

Treatment regimens for the eradication of H. pylori as suggested in Western studies may not be applicable for Iran. Herein, we conduct a systematic review to ascertain the efficacy of eradication therapy regimens used for Iranian patients and introduce the more successful treatment regimens for Iranians.

Materials and Methods:

This review was a comprehensive search of English and Farsi electronic databases conducted from June to September 2011.Results:

A total of 11 trials were included in our study. In these, there were 28 different eradication regimens studied. Of the 28 regimens, 8 had an H. pylori eradication rate of over 85% and in 3 the eradication rate was greater than 90%. In Iran, the regimens that contained amoxicillin-furazolidone or amoxicillin-clarithromycin for two weeks were the most effective for H. pylori eradication, although the furazolidone-based regimen was less expensive.

Conclusion:

For first-line treatment, the amoxicillin-furazolidone-based regimen for 2 weeks is cost-effective for H. pylori eradication in Iranian patients.