Effect of Vaccination Against Hepatitis B in Cases with Isolated Anti-HBc

Ali Kabir, Maryam Keshvari, SeyedMoayyed Alavian


Background: 1.3% of people in Iran are positive for anti-HBc antibody.The objective of this study is to determine the rate of seroconversion in those with persistent isolated anti-HBc after vaccination.

Materials and Methods: In a quasi-experimental study, 94 persons with isolated anti-HBc antibody who were referred to Tehran Blood Transfusion Organization between 2002 and 2004 were selected through a convenient sampling. They were given recombinant hepatitis B vaccine on 0, 1 and 6 months. Immunization was defined by anti-HBs antibody titer |≥|10 mIU/mL, 1-2 months after administration of the last dose.

Results: Response to HB vaccination consisted of 28%, 62% and 76% after each injection, respectively. The total response rate was 80% (n=75). Nineteen (20%) persons were negative for anti-HBs even after three doses of HB vaccination. Factors associated with decreased response to vaccination were positive anti-HBe (OR=6.4, P=0.008), history of bloodletting (OR=3.1, P=0.039) and prior history of being HBsAg positive (OR=5.6, P=0.002).

Conclusion: Although there were some differences between the response rates after each vaccine injections observed in our study and similar ones, the total response was nearly the same.


Hepatitis B, Recombinant hepatitis B vaccine, Immunogenecity, Persistent isolated anti-HBC

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