Celiac Disease and Esophageal Cancer

Masoud Khoshnia, Farhad Islami, Kareim Aghcheli, Reza Malekzadeh, Akram Pourshams


Background: Northeastern Iran has a high incidence for squamous cell esophageal carcinoma (ESCC). The aim of the study is to the assess relationship between celiac disease (CD) and ESCC.

Materials and Methods: This was a two-part, cross-sectional, case-control study performed during 2006-2011 in Gonbad,  Golestan, Iran. Serum IgA anti-tissue transglutaminase antibody levels were measured for all participants in the cross-sectional study (adult general population) as well as in ESCC cases and their matched (age and gender) controls.

Results: Out of approximately 1.3% of the 2202 individuals selected from the general population, 0.8% of 258 ESCC cases and 0.2% of 457 controls had positive IgA anti-tissue transglutaminase antibody levels.

Conclusion: The  prevalence of CD in  general population of Gonbad district is a little higher than other parts of Iran.relatively low prevalence of IgA anti-tissue transglutaminase antibody in ESCC cases in northeastern Iran does not support the presumption that CD is a major factor for the high incidence of ESCC in the region. However, as there is little higher prevalence of positivity for the antibody in ESCC cases than in controls, a cohort study of Celiac disease patients  is  much more  suitable study to assess the relation between CD and ESCC.


Esophageal cancer; Celiac disease; Iran

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