Noscapine and Acute Pancreatitis: Effects of Different Doses of Noscapine on Serum Amylase Level in Experimental Acute Pancreatitis in Rats

Abstract

Introduction and Aims: Noscapine has been recently known as an antagonist of Bradykinin, and in this study its effect on the animal model of acute pancreatitis has been evaluated.

Materials and Methods: 49 male Wistar rats have been evaluated in five experimental and four control groups. Common bile duct has been ligated by means of surgery to induce acute pancreatitis in rats. The resulted inflammation of the pancreas and the effect of Noscapine on it have been documented by measuring serum amylase levels. Amylase was measured in experimental groups after surgery and injection of Noscapine. Amylase was also measured in control groups while they did not undergo similar procedures.

Results: The only meaningful effect of Noscapine values on the level of serum amylase was an unexpected increase in the 0.5 mg/kg dose; and in other doses (1, 2, 5, 10 mg/kg) the changes in the level of serum amylase were not meaningful.

Conclusions: Noscapine has affected the inflammation of acute pancreatitis via probable mediation of Bradykinin, but the inflammation was not favorably reduced, probably because of short lifetime of Noscapine.