Clinical Findings of Patients with Pancreatic Insulinoma in Shariati Hospital, Tehran, Iran(2010-2013)

Abstract

Background:

Insulinoma  was a rare pancreatic neuroendocrine tumor. Insulinoma  was more likely to present as one small size tumor in head of pancreas in middle age .Surgery  was  a curative treatment.The aim of this study was to present clinical characteristics of insulinoma tumors in pancreas and their outcomes after tumor resection from a referral endosonography center in Iran.

Materials and Methods:

this was cross sectional study from Nov 2010 to Nov 2013, all patients with clinical and biochemichal diagnosis of insulinoma entered to the study. Various characteristics likes, symptoms, laboratory and imaging findings,pathologic reports and their outcomes after surgery were recorded in a standard check list. Patients were followed for up to three years. All statistical analyses were performed SPSS software.

Results:

A total of 42 patients (62% women;  mean of  age 40 years) were identified.All of patients reported Whipple’s triad .Mean time from initiating of symptoms  untill diagnosis time was 14 months. The common blood type was O (n=22,52.3%).The mean tumor size was 2.7cm. 33.4% of endosonography reports  show  a solid tumor in the head of pancreas.  Finding shows (n=36, 85%) of patients were treated surgically. Insulinoma tumor was confirmed in the pancreatic sample. Insulinoma recurrence  have not report during the mean follow-up of 343 days in patients after tumor resection.

Conclusion:

In this study, insulinoma tumors of pancreas (non familial) were single with tumor size of less than 3 cm .Most of them located in the head of pancreas. Outcomes following complete resection of tumor were satisfactory and  have not report tumor recurrence during up to 3 years follow up. These results were the same as reports from other countries.